|Role of Thymosin β4 in Myocardial Infarction: a review
Desalegn Getnet Demsie, Rajesh Kumar Sharma, Desye Gebrie, Deepak Nathiya
October-December 2019, 4(4):1-5
Thymosin -Beta4 is a 43 amino acid, actin sequestering polypeptide. Like other TBs its distribution is not organ specific and found abundantly in the cytosol, nucleus, and extracellular space of many cell types. It shares high degree of sequence homologythymosin B10. Thymosin beta-4 (TB-4) plays key physiological roles in the cardio vascular disorders by significantly reducing cardiac fibrosis and left ventricular function. Thymosin beta-4 facilitates tissue development, maintenance of pathological processes; it promotes the formation of new myocytes, decreases apoptosis (7), slows the process of cell aging while increasing the cell proliferation (10), thus improving cardiac infarcted heart (6).Using thymosinB4 cardiac fibroblasts can be reprogrammed into cardiomyocyte-like cells in their native environment for potential regenerative purpose. Angiogenesis and vasculogenesis, in cardiac remodeling, are promoted using thymosin Beta 4. Scar formation in cardiovascular disorders like, myocardial infarction could be reversed by applying the usage of thymosin B4.
Furthermore, thymosin B4 can treat neuronal cell death or injury, including injuries caused by stroke or trauma and injuries caused by neurological and neurodegenerative disease. The structural basis of the nervous system such as cell proliferation, migration, neuronal differentiation, axonal growth and synaptogenesis, as well as for the genesis and differentiation can be promoted and maintained with thymosin B4. Therefore, thymosinB4 can be used in the treatment of neurodegenerative disorders.
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