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ORIGINAL ARTICLE
Year : 2017  |  Volume : 2  |  Issue : 2  |  Page : 18-23

Does sequential therapy for Helicobacter pylori share the risk factors of triple therapy failure? A prospective randomized study


1 Department of Gastroenterology II, Mohamed V Teaching Military Hospital, Rabat 10100, Morocco
2 Laboratory of Pharmacology and Toxicology, Medical and Pharmacy School, Rabat, BP 6203, Rabat 10100, Morocco

Correspondence Address:
Tarik Adioui
Department of Gastroenterology II, Mohamed V Teaching Military Hospital, Rabat 10100
Morocco
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Source of Support: None, Conflict of Interest: None


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Background: Predicting factors for the outcome of conventional Helicobacter pylori triple therapy have been enumerated. Among these, high clarithromycin resistance and smoking are predictors of treatment failure. What about sequential therapy? Aim: To detect predicting factors for the outcome of Helicobacter pylori eradication using sequential therapy and standard triple therapy. Methods: A total of 306 naive H. pylori-infected patients, were assigned randomly to one of two treatment groups: standard triple therapy [omeprazole + amoxicillin + clarithromycin for 7 days] or sequential therapy [omeprazole + amoxicillin for 5 days, followed by omeprazole + tinidazole + clarithromycin for an additional 5 days]. Age, sex, smoking, endoscopic and histological findings were considered as candidates for a model of multivariate analysis which used therapeutic outcome as the dependent variable. Results: The sequential scheme was statistically more effective than standard triple therapy. Smoking (P < 0.05) was significantly associated with the failure of triple therapy, but the effectiveness of sequential treatment was not predicted by this factor. Conclusion: Our data suggest that sequential therapy is not affected by a host factor (smoking), which has, until now, predicted the outcome of standard triple therapy.


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