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Year : 2017  |  Volume : 2  |  Issue : 1  |  Page : 5-9

Vertical transmission of hepatitis b surface antigen positive mothers in central women hospital, Mandalay, Myanmar

1 Assistant Pediatrician, 550bedded Mandalay Children Hospital, Mandalay, Myanmar
2 Professor, Special Care Baby Unit, Central Women's Hospital, Mandalay, Myanmar
3 Professor and Head of Department of Pediatrics, University of Medicine, Mandalay, Myanmar

Correspondence Address:
San Yu Maw
Assistant Pediatrician, 550bedded Mandalay Children Hospital, Mandalay
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Source of Support: None, Conflict of Interest: None

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Aim: To determine the vertical transmission rate of hepatitis B surface antigen (HBsAg) positive mothers and to find out the associated factors of vertical transmission of hepatitis B virus in Central Women Hospital (CWH), Mandalay. Methods: Hospital based cross-sectional analytic study was conducted on 150 HBsAg positive mothers and their newborns delivered at CWH, Mandalay between 1st February 2014 and 31st January 2015.Pre-structured questionnaire was used to collect background characteristics of mothers. Hepatitis B e antigen (HBeAg) status of mothers, preterm premature rupture of membranes (PPROM) and mode of delivery were noted by reviewing medical records of the mother. Gestational assessment of newborns was done. Blood samples from the newborns were collected immediately after birth to determine the HBsAg status of the newborn. Results: The vertical transmission rate of HBsAg was 20%. The vertical transmission rate was found to be associated with low socioeconomic status of mothers (OR 3; 95% CI, 1.2-7.6), HBeAg positivity in mothers (OR 14.5; 95% CI, 4.9-43.4) and preterm delivery (OR 4.7; 95% CI, 1.9-11.6). Conclusion: The vertical transmission rate of HBs Ag in this study was high. Maternal HBeAg positivity, low socioeconomic status of mothers and preterm delivery were found to be associated with the vertical transmission rate. Appropriate prophylaxis for newborns of HBsAg-positive mothers should be advocated as a government support program.

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