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REVIEW ARTICLE
Year : 2016  |  Volume : 1  |  Issue : 1  |  Page : 48-54

Effects of long term proton pump inhibitors use in pediatrics


Unit of Paediatric Gastroenterology, Hospital Pediátrico Integrado, Centro Hospitalar Sào Joào, Alameda Prof. Hernàni Monteiro, 4202-451 Porto, Portugal

Correspondence Address:
Marta Tavares
Unit of Paediatric Gastroenterology, Hospital Pediátrico Integrado, Centro Hospitalar Sào Joào, Alameda Prof. Hernàni Monteiro, 4202-451 Porto
Portugal
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Source of Support: None, Conflict of Interest: None


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We review the physiology of gastric acid secretion and main clinical complications of hypochloridria in childhood. It has become a common practice to treat infants and children who have suspected gastroesophageal reflux disease by using acid-suppressive medications empirically. Multiple studies in adult patients indicate an increase in risk of infection, nutritional impairment and imunological complications literature update is revisited in order to summarize acid-suppressive medications adverse effects in infants and children on long-term use.


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