| REVIEW ARTICLE |
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| Year : 2016 | Volume
: 1
| Issue : 1 | Page : 48-54 |
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Effects of long term proton pump inhibitors use in pediatrics
Marta Tavares, Eunice Trindade, Jorge Amil Dias
Unit of Paediatric Gastroenterology, Hospital Pediátrico Integrado, Centro Hospitalar Sào Joào, Alameda Prof. Hernàni Monteiro, 4202-451 Porto, Portugal
Correspondence Address:
Marta Tavares
Unit of Paediatric Gastroenterology, Hospital Pediátrico Integrado, Centro Hospitalar Sào Joào, Alameda Prof. Hernàni Monteiro, 4202-451 Porto
Portugal
 Source of Support: None, Conflict of Interest: None
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We review the physiology of gastric acid secretion and main clinical complications of hypochloridria in childhood. It has become a common practice to treat infants and children who have suspected gastroesophageal reflux disease by using acid-suppressive medications empirically. Multiple studies in adult patients indicate an increase in risk of infection, nutritional impairment and imunological complications literature update is revisited in order to summarize acid-suppressive medications adverse effects in infants and children on long-term use.
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