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ORIGINAL ARTICLE
Year : 2016  |  Volume : 1  |  Issue : 1  |  Page : 15-19

Liver Transplantation In Young Children: Japanese Experience


Director, Organ Transplantation, National Children’s Hospital, Tokyo, Japan

Correspondence Address:
Mureo Kasahara
Director, Organ Transplantation, National Children’s Hospital, Tokyo
Japan
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Source of Support: None, Conflict of Interest: None


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Organ transplantation center, Tokyo Japan reviews the experience of liver transplantation in young children. Based on 27 years experience, since the living donor liver transplantation was first performed in Japan, some of the newer developments necessity by paucity of organs and desire for decreasing mortality and morbidity are presented in this paper. From one transplant in 1989 the number has stabilized around average of 400+ every year. Children have formed significant number of these cases (Adults >18 Yr. n=4992; Children<18 Yr.= 2751). Indications for which these cases were performed are listed. The indications of pediatric liver transplantation have been refined and those are now followed in National Center for Child Health and Development. Technical refinements especially those decrease the parenchymal cell injury to liver meant for transplantation in children weighing less <5 kg receiving adult liver (large for size grafts) are illustrated in step wise manner. The modified left lateral segment reduction by which transplant could be done in very small infants. An algorithm proposed by our experience which takes into account factors like graft thickness and abdominal AP diameter is introduced. In our opinion further refinement of this algorithm is needed.


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